Z-VAD (OMe) -FMK

Z-VAD (OMe) -FMK (Z-Val-Ala-Asp (OMe) -FMK) is a cell-permeable and irreversible pan-caspase inhibitor[1]. Z-VAD (OMe) -FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD (OMe) -FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1[2].

Product Specifications

CAS Number

[187389-52-2]

Product Name Alternative

Z-Val-Ala-Asp (OMe) -FMK

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Caspase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Z-VAD-FMK.html

Purity

98.20

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CF)[C@H](CC(OC)=O)NC([C@H](C)NC([C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O

Molecular Formula

C22H30FN3O7

Molecular Weight

467.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Kawasaki M, et al. Protection from lethal apoptosis in lipopolysaccharide-induced acute lung injury in mice by a caspaseinhibitor. Am J Pathol. 2000 Aug;157 (2) :597-603.|[2]Park S, et al. Neurovascular protection reduces early brain injury after subarachnoid hemorrhage. Stroke. 2004 Oct;35 (10) :2412-7.|[3]Ilangovan R, et al. Inhibition of apoptosis by Z-VAD-fmk in SMN-depleted S2 cells. J Biol Chem. 2003 Aug 15;278 (33) :30993-9.|[4]Davies CW, et al. The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE (OMe) -FMK) . Bioorg Med Chem Lett. 2012 Jun 15;22 (12) :3900-4.