8-iso-15-keto Prostaglandin F2β

8-iso Prostaglandin F2β is a non-enzymatic isoprostane formed via free radical peroxidation of arachidonic acid. It exhibits species-specific vasoactivity, weakly contracting canine and porcine pulmonary veins but showing minimal effect on human umbilical vessels and platelet aggregation. Its potential metabolite, 8-iso-15-keto PGF2β, remains uncharacterized, making the parent compound a research tool for studying oxidative stress and isoprostane pharmacology.