PF-06843195
PF-06843195 is a selective PI3Kα inhibitor that blocks PIP2 phosphorylation to PIP3, suppressing AKT signaling. It demonstrates anti-tumor efficacy in cellular assays and animal models, supporting its use in oncology research focused on PI3K/AKT pathway dysregulation.
Product Specifications
CAS Number
2067281-51-8
Product Name Alternative
PF06843195, PF-06843195, PF 06843195
Field of Research
Signal Transduction
Purity
98.01% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.01 mM) ; DMSO:50 mg/mL (100.31 mM)
Smiles
N ([C@]1 (CO) CN (C (OCC (F) F) =O) CC1) C=2C (F) =C (N=C (N2) N3CCOCC3) C=4C=NC (N) =NC4
Molecular Formula
C20H25F3N8O4
Molecular Weight
498.46
Storage Conditions
-20°C
Notes
For research use only.
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