IL-4-inhibitor-1
This small molecule IL-4 inhibitor selectively binds IL-4 (Kd = 1.8 μM) to block the IL-4/JAK1/STAT6 signaling pathway, as demonstrated by its inhibition of IL-4-induced STAT6 phosphorylation in THP-1 cells. It is a valuable research tool for studying type 2 immune responses in asthma and allergy models, both in vitro and in vivo.
Product Specifications
CAS Number
1332184-63-0
Product Name Alternative
IL4inhibitor1, IL-4-inhibitor-1, IL-4, ILReceptor, IL Receptor, IL 4 inhibitor 1
Field of Research
Immunology & Inflammation, Immunology & Inflammation; Pharmacology & Drug Discovery
Purity
98.26% (May vary between batches)
Solubility
Ethanol:10 mg/mL (31.12 mM) ; DMF:27 mg/mL (84.03 mM) ; DMSO:PBS (pH 7.2) (1:5) :0.1 mg/mL (0.31 mM) ; DMSO:50 mg/mL (155.61 mM)
Smiles
Nc1nc (cc (-c2ccc (O) c (O) c2) c1C#N) -c1ccc (F) cc1
Molecular Formula
C18H12FN3O2
Molecular Weight
321.31
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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