Sorafenib N-oxide

Sorafenib N-oxide, an active metabolite of sorafenib, is a potent and selective inhibitor of FLT3-ITD mutant kinase, showing efficacy in cellular models of acute myeloid leukemia (AML) . It also acts as a linear-mixed inhibitor of CYP3A4. This compound is a valuable research tool for studying targeted therapies in FLT3-ITD-driven AML and investigating drug-drug interaction potentials.