Fascaplysin
Fascaplysin is a selective CDK4/cyclin D1 inhibitor (IC50 = 0.35 μM) that triggers caspase-dependent apoptosis and autophagy crosstalk via PI3K/AKT/mTOR pathway suppression. This mechanism has been demonstrated in vitro in human leukemia HL-60 cells, supporting its research use in oncology and cell cycle studies.
Product Specifications
CAS Number
114719-57-2
Field of Research
Cardiovascular Research, Cell Biology
Purity
>98%
Bioactivity
CDK4 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 20 mg/ml) or in Water (up to 2 mg/ml)
Smiles
[Cl-].O=C1C2=C (C=CC=C2) [N+]2=C1C1=C (C=C2) C2=CC=CC=C2N1
Molecular Formula
C18H11ClN2O4
Molecular Weight
306.75
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
12,13-Dihydro-13-oxopyrido[1,2-a:3,4-b’]diindol-5-ium chloride
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