TAS-119
TAS-119 is a highly selective, orally bioavailable Aurora A kinase inhibitor (IC50 = 1.0 nM) with significant activity against Aurora B (IC50 = 95 nM) . It demonstrates potent antitumor and antimitotic activity in preclinical studies, supporting its investigation in cancer research, including in vivo models of solid tumors.
Product Specifications
CAS Number
1453099-83-6
Product Name Alternative
AuroraKinase, Aurora Kinase, Aurora B, Aurora A, TAS119, TAS-119, TAS 119, TAS 2104, TAS2104, TAS-2104
Field of Research
Cell Biology, Epigenetics & Chromatin
Purity
98.69% (May vary between batches)
Solubility
DMSO:45 mg/mL (88.87 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.95 mM)
Smiles
Cc1cc (Nc2nc (CC3 (CCN (CC3) C (=O) c3cccc (Cl) c3Cl) C (O) =O) ccc2F) n[nH]1
Molecular Formula
C23H22Cl2FN5O3
Molecular Weight
506.36
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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