ML 209
ML-209 is a potent small molecule antagonist of the nuclear receptor RORγt, inhibiting its transcriptional activity with an IC50 of 300 nM in cellular assays. It effectively blocks the RORγt-dependent differentiation of naive human CD4+ T cells into pro-inflammatory Th17 cells, making it a valuable research tool for studying autoimmune and inflammatory diseases in both in vitro and in vivo contexts.
Product Specifications
CAS Number
1334526-14-5
Product Name Alternative
ML 209, ML209, ML-209, RORγt
Field of Research
Metabolism Research
Purity
98.81% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:1.5 mg/mL (3.4 mM) ; DMSO:18.33 mg/mL (41.52 mM)
Smiles
C (CC (=O) N1C[C@@H] (C) C[C@@H] (C) C1) (C2=C (OC) C=C (OC) C=C2O) C=3C=C4C (=CC3) OCO4
Molecular Formula
C25H31NO6
Molecular Weight
441.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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