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ML 209

ML-209 is a potent small molecule antagonist of the nuclear receptor RORγt, inhibiting its transcriptional activity with an IC50 of 300 nM in cellular assays. It effectively blocks the RORγt-dependent differentiation of naive human CD4+ T cells into pro-inflammatory Th17 cells, making it a valuable research tool for studying autoimmune and inflammatory diseases in both in vitro and in vivo contexts.

Product Specifications

CAS Number

1334526-14-5

Product Name Alternative

ML 209, ML209, ML-209, RORγt

Field of Research

Metabolism Research

Purity

98.81% (May vary between batches)

Solubility

10% DMSO+90% Corn Oil:1.5 mg/mL (3.4 mM) ; DMSO:18.33 mg/mL (41.52 mM)

Smiles

C (CC (=O) N1C[C@@H] (C) C[C@@H] (C) C1) (C2=C (OC) C=C (OC) C=C2O) C=3C=C4C (=CC3) OCO4

Molecular Formula

C25H31NO6

Molecular Weight

441.52

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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