ErbB2, phosphorylated (Tyr877) (c-erbB2, HER2, neu Oncoprotein)

May be stored at 4 °C for short-term only. For long-term storage, store at -20 °C. Aliquots are stable for at least 12 months at -20 °C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Recognizes endogenous levels of human ErbB2 only when phosphorylated at tyrosine 877 at ~185kD. May crossreact with other ErbB family members (e.g., EGF receptor) when their homologous tyrosines are phosphorylated, but it does not crossreact with other tyrosine-phosphorylated proteins. Species sequence homology: mouse and rat.

[ERBB2; ERBB2; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)]