R-8507
R-8507 is a small molecule TNF-αRI antagonist that inhibits TNF-α- and IL-1β-induced ICAM-1 expression in A549 cells. It blocks TNF-αRI internalization by disrupting RIP1 and TRADD interactions, making it a useful research tool for studying inflammation and cell signaling pathways in vitro.
Product Specifications
CAS Number
338773-13-0
Field of Research
Cell Biology, Immunology & Inflammation, Signal Transduction
Smiles
FC (F) (F) C1=NC2=CC=CC=C2N2C (=NN=C12) C1=CC=C (Cl) C=C1
Molecular Formula
C16H8ClF3N4
Molecular Weight
348.71
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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