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R-8507

R-8507 is a small molecule TNF-αRI antagonist that inhibits TNF-α- and IL-1β-induced ICAM-1 expression in A549 cells. It blocks TNF-αRI internalization by disrupting RIP1 and TRADD interactions, making it a useful research tool for studying inflammation and cell signaling pathways in vitro.

Product Specifications

CAS Number

338773-13-0

Field of Research

Cell Biology, Immunology & Inflammation, Signal Transduction

Smiles

FC (F) (F) C1=NC2=CC=CC=C2N2C (=NN=C12) C1=CC=C (Cl) C=C1

Molecular Formula

C16H8ClF3N4

Molecular Weight

348.71

Storage Conditions

-20°C

Notes

For research use only.

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