Patulin

Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage[1][2][3][4].

Product Specifications

CAS Number

[149-29-1]

Product Name Alternative

Terinin

UNSPSC

12352005

Hazard Statement

H300, H315

Target

Antibiotic; Apoptosis; Autophagy; Bacterial

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/patulin.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic; warming)

Smiles

O=C1OC2=CCOC(C2=C1)O

Molecular Formula

C7H6O4

Molecular Weight

154.12

Precautions

H300, H315

References & Citations

[1]Puel O, et al. Biosynthesis and toxicological effects of patulin. Toxins (Basel) . 2010 Apr;2 (4) :613-31.|[2]Glaser N, et al. Patulin: Mechanism of genotoxicity. Food Chem Toxicol. 2012 May;50 (5) :1796-801.|[3]Sun M, et al. Patulin Induces Autophagy-Dependent Apoptosis through Lysosomal-Mitochondrial Axis and Impaired Mitophagy in HepG2 Cells. J Agric Food Chem. 2018 Nov 21;66 (46) :12376-12384.|[4]Glaser N, et al. Patulin: Mechanism of genotoxicity. Food Chem Toxicol. 2012 May;50 (5) :1796-801.