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GSK143

GSK143 is a potent, selective, and orally bioavailable SYK inhibitor (pIC50 7.5) that also suppresses pErk (pIC50 7.1) . It demonstrates anti-inflammatory activity in vivo by reducing immune cell infiltration in mouse intestinal muscularis, making it a valuable tool for researching SYK-related pathways in immunology and inflammation models.

Product Specifications

CAS Number

1240390-27-5

Field of Research

Cardiovascular Research, Signal Transduction

Smiles

Cc1ccc (Nc2nc (N[C@@H]3CCOC[C@@H]3N) ncc2C (N) =O) cc1

Molecular Formula

C17H22N6O2

Molecular Weight

342.403

Storage Conditions

-20°C

Notes

For research use only.

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