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HG-7-85-01

HG-7-85-01 is a potent ATP-competitive, type II inhibitor targeting BCR-ABL (including T315I mutant), PDGFRα, Kit, and Src kinases. It demonstrates robust anti-proliferative activity in vitro, inducing cell cycle arrest and apoptosis in leukemia cell lines, and has shown efficacy in preclinical in vivo models of BCR-ABL-driven cancers.

Product Specifications

CAS Number

1258391-13-7

Product Name Alternative

HG78501, HG-7-85-01, HG 7 85 01

Field of Research

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Purity

98.08% (May vary between batches)

Solubility

DMSO:100 mg/mL (164.29 mM)

Smiles

O=C (NC1=CC=C (C (=C1) C (F) (F) F) CN2CCN (CC) CC2) C3=CC=CC (=C3) C4=NC=5SC (=NC5C=C4) NC (=O) C6CC6

Molecular Formula

C31H31F3N6O2S

Molecular Weight

608.68

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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