EW-7195
EW-7195 is a potent and selective ALK5 (TGFβR1) inhibitor (IC50 = 4.83 nM) that effectively blocks TGF-β1-induced Smad signaling and EMT. It has demonstrated activity in inhibiting breast cancer metastasis to the lung in research models, supporting its use in studying fibrosis and cancer biology.
Product Specifications
CAS Number
1352609-28-9
Product Name Alternative
Smad, TGF-beta/Smad, TGFbeta/Smad, TGF-beta, TGFbeta, TGF-β/Smad, TGFβ, TGF-b/Smad, TGFb, ALK5, EW 7195, EW-7195, EW7195
Field of Research
Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.76% (May vary between batches)
Solubility
DMSO:40 mg/mL (98.42 mM)
Smiles
Cc1cccc (n1) -c1[nH]c (CNc2cccc (c2) C#N) nc1-c1ccc2ncnn2c1
Molecular Formula
C23H18N8
Molecular Weight
406.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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