Taletrectinib free base
Taletrectinib free base (AB-106) is a potent, selective, and orally active small molecule inhibitor targeting ROS1 and NTRK kinases. It demonstrates low nanomolar IC50 values against wild-type ROS1, NTRK1/2/3, and several crizotinib-resistant ROS1 mutants like G2032R. This inhibitor is utilized in preclinical oncology research for studying targeted therapies in both cellular and animal models of ROS1- or NTRK-driven cancers.
Product Specifications
CAS Number
1505514-27-1
Product Name Alternative
ROS Kinase, ROS1, ROSKinase, Taletrectinib, Taletrectinib free base, AB-106freebase, DS-6051b, DS-6051b free base, IBI344, IBI-344, IBI-344 free base, IBI 344
Field of Research
Signal Transduction
Purity
99.87% (May vary between batches)
Solubility
DMSO:55 mg/mL (135.65 mM)
Smiles
N ([C@H] (C) C1=CC (F) =CC=C1) C2=NN3C (=CN=C3C=C2) C4=CC=C (OC[C@@H] (C) N) C=C4
Molecular Formula
C23H24FN5O
Molecular Weight
405.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
124352-AP 100 µL
CASP1 (Caspase-1, CASP-1, Interleukin-1 beta Convertase, IL-1BC, Interleukin-1 beta-Converting Enzyme, IL-1 beta-converting Enzyme, ICE, p45, Caspase-1 Subunit p20, Caspase-1 Subunit p10, IL1BCE, IL1BC, CASP1) (AP) discontinued
Sign In for Pricing
View Details 
ARP49753_T100-HRP 100 µL
FNDC3B Antibody - N-terminal region : HRP (ARP49753_T100-HRP)
Sign In for Pricing
View Details 
MBS6390901-01 0.1 mL
Prolactin Receptor (PRLR, PRL-R, PRL Receptor) (AP)
Sign In for Pricing
View Details MBS6390901-02 5x 0.1 mL
Prolactin Receptor (PRLR, PRL-R, PRL Receptor) (AP)
Sign In for Pricing
View Details E55A11034 50 Tests
Canine IgE, kappa Isotype Control antibody , FITC
Sign In for Pricing
View Details 