Atuzabrutinib
Atuzabrutinib (SAR 444727) is a selective Bruton's tyrosine kinase (Btk) inhibitor that suppresses neutrophil activation by blocking adhesion receptor signaling. This small molecule is utilized in research models of autoimmune diseases, including rheumatoid arthritis and pemphigus vulgaris, for both in vitro mechanistic studies and in vivo preclinical investigations.
Product Specifications
CAS Number
1581714-49-9
Product Name Alternative
Btk, Atuzabrutinib, PRN473, PRN-473, PRN 473, SAR 444727, SAR444727, SAR-444727
Field of Research
Cardiovascular Research, Signal Transduction
Purity
97.27% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:3.3 mg/mL (6.12 mM) ; DMSO:80 mg/mL (148.26 mM)
Smiles
NC1=C2C (N (N=C2C3=C (F) C=C (OC4=CC=CC=C4) C=C3) [C@H]5CN (C (/C (=C/C (C) (C) C) /C#N) =O) CCC5) =NC=N1
Molecular Formula
C30H30FN7O2
Molecular Weight
539.6
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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