(3S,4S) -PF-06459988
(3S,4S) -PF-06459988 is the less active stereoisomer of a potent and irreversible inhibitor targeting the EGFR T790M mutant. Its design incorporates a minimally reactive electrophile, conferring high selectivity over wild-type EGFR, making it a valuable tool compound for in vitro mechanistic studies of mutant-specific EGFR inhibition in cancer research.
Product Specifications
CAS Number
1858291-14-1
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
CO[C@@H]1CN (C[C@H]1COc1nc (Nc2cnn (C) c2) nc2[nH]cc (Cl) c12) C (=O) C=C
Molecular Formula
C19H22ClN7O3
Molecular Weight
431.88
Storage Conditions
-20°C
Notes
For research use only.
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