CC-99677
CC-99677 (Gamcemetinib) is a covalent, selective MK2 inhibitor developed for autoimmune disease research. It exhibits potent biochemical (IC50=156.3 nM) and cellular (EC50=89 nM in THP-1 cells) activity by blocking HSP27 phosphorylation via an SNAr mechanism. Its profile supports investigation into inflammatory pathways in both in vitro and in vivo models.
Product Specifications
CAS Number
1887069-10-4
Product Name Alternative
Gamcemetinib, HSP, MAPKAPK2 (MK2), CC 99677, CC99677, CC-99677
Field of Research
Metabolism Research, Signal Transduction
Purity
99.51% (May vary between batches)
Solubility
DMSO:14.1 mg/mL (30 mM)
Smiles
CCOCc1cnc (Cl) nc1Oc1ccc2c3c4NC[C@@H] (C) NC (=O) c4sc3ccc2n1
Molecular Formula
C22H20ClN5O3S
Molecular Weight
469.94
Storage Conditions
-20°C
Notes
For research use only.
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