EZH2-IN-4
EZH2-IN-4 is a potent, orally bioavailable small molecule inhibitor of both wild-type and mutant EZH2, with IC50 values of 0.923 nM and 2.65 nM, respectively. It demonstrates significant anti-tumor activity in preclinical models, supporting its use in oncology research for studying epigenetic mechanisms in vitro and in vivo.
Product Specifications
CAS Number
2088132-99-2
Field of Research
Epigenetics & Chromatin
Smiles
[H][C@@]1 (CC[C@@H] (CC1) N1CC (C1) OC) [C@@H] (C) c1sc2CCCN (Cc3c (C) cc (C) [nH]c3=O) C (=O) c2c1C |wU:13.15,1.14, wD:4.7,1.0, (-2.14, -2.64, ; -3.68, -2.64, ; -2.91, -3.98, ; -3.68, -5.31, ; -5.22, -5.31, ; -5.99, -3.98, ; -5.22, -2.64, ; -5.99, -6.64, ; -5.59, -8.13, ; -7.08, -8.53, ; -7.48, -7.04, ; -7.85, -9.86, ; -9.39, -9.86, ; -2.91, -1.31, ; -3.68, .03, ; -1.37, -1.31, ; -.46, -.06, ;1, -.54, ;2.21, .42, ;3.71, .08, ;4.37, -1.31, ;3.71, -2.7, ;4.67, -3.9, ;6.19, -3.67, ;6.75, -2.24, ;5.79, -1.03, ;8.27, -2.01, ;9.23, -3.21, ;10.76, -2.98, ;8.67, -4.65, ;7.15, -4.87, ;6.59, -6.31, ;2.21, -3.04, ;1.86, -4.54, ;1, -2.08, ; -.46, -2.55, ; -.94, -4.02, ) |
Molecular Formula
C29H41N3O3S
Molecular Weight
511.73
Storage Conditions
-20°C
Notes
For research use only.
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