(R) -GSK-3685032

(R) -GSK-3685032 is the R-enantiomer of a potent, selective, reversible, and non-covalent DNMT1 inhibitor (IC50 = 36 nM) . This first-in-class compound induces DNA demethylation, reactivates gene transcription, and inhibits cancer cell proliferation, making it a valuable tool for epigenetic research in oncology, both in vitro and in vivo.