(R) -GSK-3685032
(R) -GSK-3685032 is the R-enantiomer of a potent, selective, reversible, and non-covalent DNMT1 inhibitor (IC50 = 36 nM) . This first-in-class compound induces DNA demethylation, reactivates gene transcription, and inhibits cancer cell proliferation, making it a valuable tool for epigenetic research in oncology, both in vitro and in vivo.
Product Specifications
CAS Number
2170140-50-6
Field of Research
Epigenetics & Chromatin
Smiles
CCc1c (C#N) c (S[C@@H] (C (N) =O) c2ccccc2) nc (N2CCC (N) CC2) c1C#N
Molecular Formula
C22H24N6OS
Molecular Weight
420.54
Storage Conditions
-20°C
Notes
For research use only.
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