AHR agonist 3
Product Specifications
UNSPSC Description
AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research[1].
Target Antigen
Apoptosis; Aryl Hydrocarbon Receptor
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ahr-agonist-3.html
Purity
99.79
Solubility
DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
C1=CC=C2C(=C1)N=C3C4=CC=CC5=C4C(=CC=C5)C(=O)N23
Molecular Weight
270.28
References & Citations
[1]Elson DJ, et.al. Induction of Aryl Hydrocarbon Receptor-Mediated Cancer Cell-Selective Apoptosis in Triple-Negative Breast Cancer Cells by a High-Affinity Benzimidazoisoquinoline. ACS Pharmacol Transl Sci. 2023 Jun 7;6(7):1028-1042.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W338764/AHR-agonist-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W338764/AHR-agonist-3-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
23749-58-8
Available Sizes
Curated Selection
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