AHR agonist 3

AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research[1].

Product Specifications

CAS Number

[23749-58-8]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Aryl Hydrocarbon Receptor

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ahr-agonist-3.html

Purity

99.79

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C1=CC=C2C(=C1)N=C3C4=CC=CC5=C4C(=CC=C5)C(=O)N23

Molecular Formula

C18H10N2O

Molecular Weight

270.28

Precautions

H315, H319, H335

References & Citations

[1]Elson DJ, et.al. Induction of Aryl Hydrocarbon Receptor-Mediated Cancer Cell-Selective Apoptosis in Triple-Negative Breast Cancer Cells by a High-Affinity Benzimidazoisoquinoline. ACS Pharmacol Transl Sci. 2023 Jun 7;6 (7) :1028-1042.