NAChR agonist CMPI hydrochloride

CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) targeting the α4:α4 interface of nicotinic acetylcholine receptors. It enhances ACh responses at (α4) 3 (β2) 2 nAChRs (EC50 0.26 μM) and serves as a valuable research tool for studying nicotine dependence and neuropsychiatric disorders associated with cholinergic hypofunction in both in vitro and in vivo models.