TH5427 hydrochloride

TH5427 hydrochloride is a potent and selective NUDT5 inhibitor (IC50 = 29 nM) with 690-fold selectivity over MTH1. It blocks progestin-driven, PAR-dependent nuclear ATP production in breast cancer cells, inhibiting chromatin remodeling, gene expression, and cell proliferation in vitro. This makes it a valuable chemical probe for studying nucleotide metabolism in cancer research.