XZ739
XZ739 is a potent, Cereblon-dependent PROTAC that selectively degrades BCL-XL, inducing caspase-mediated apoptosis. It demonstrates high potency with a DC50 of 2.5 nM in MOLT-4 cells and is a valuable chemical probe for studying apoptosis and BCL-2 family biology in cancer research.
Product Specifications
CAS Number
2365172-19-4
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Smiles
CN (CCOCCOCCOCCNc1cccc2C (=O) N (C3CCC (=O) NC3=O) C (=O) c12) CC[C@H] (CSc1ccccc1) Nc1ccc (cc1S (=O) (=O) C (F) (F) F) S (=O) (=O) NC (=O) c1ccc (cc1) N1CCN (CC2=C (CCC (C) (C) C2) c2ccc (Cl) cc2) CC1 |t:81|
Molecular Formula
C65H76ClF3N8O12S3
Molecular Weight
1349.99
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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