GNE-274
GNE-274 is a structurally related, non-degrading analog of GDC-0927 that functions as a potent ERα LBD inhibitor and partial agonist. Unlike degraders, it increases chromatin accessibility at ER binding sites without inducing receptor turnover, making it a valuable tool for studying ER-driven transcription and resistance mechanisms in breast cancer cell models.
Product Specifications
CAS Number
2369048-69-9
Field of Research
Metabolism Research
Smiles
CCCN1CC (COc2ccc (cc2) [C@@H]2Oc3ccc (O) cc3C (C) =C2c2cccc (O) c2) C1
Molecular Formula
C29H31NO4
Molecular Weight
457.57
Storage Conditions
-20°C
Notes
For research use only.
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