MS98
MS98 is a potent and selective PROTAC that induces degradation of total AKT (pan-AKT1/2/3) with a DC50 of 78 nM, exhibiting high-affinity binding to AKT isoforms. This degrader is a valuable chemical tool for probing AKT-dependent signaling in cancer research, applicable in both cellular and in vivo models to study oncogenesis and therapeutic resistance.
Product Specifications
CAS Number
2376137-31-2
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
C[C@H] (NC (=O) [C@@H]1C[C@@H] (O) CN1C (=O) [C@@H] (NC (=O) CCCCCCCCCCC (=O) NCCNC[C@@H] (C (=O) N1CCN (CC1) c1ncnc2[C@H] (O) C[C@@H] (C) c12) c1ccc (Cl) cc1) C (C) (C) C) c1ccc (cc1) -c1scnc1C
Molecular Formula
C58H81ClN10O7S
Molecular Weight
1097.86
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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