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Bexotegrast

Bexotegrast (PLN-74809) is a potent, orally bioavailable dual inhibitor of αvβ6 and αvβ1 integrins that blocks TGF-β activation. Its antifibrotic properties are being investigated in preclinical and clinical research for fibrotic lung diseases, including idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP) .

Product Specifications

CAS Number

2376257-44-0

Product Name Alternative

PLN-74809, αVβ6 integrin, αVβ1 integrin, Bexotegrast

Field of Research

Signal Transduction

Purity

99.53% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.12 mM) ; DMSO:100 mg/mL (203 mM)

Smiles

N ([C@@H] (CCN (CCCCC=1NC=2C (=CC1) CCCN2) CCOC) C (O) =O) C=3C4=C (N=CN3) C=CC=C4

Molecular Formula

C27H36N6O3

Molecular Weight

492.61

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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