RMC-6272
RMC-6272 (RM-006) is a potent and selective bi-steric mTORC1 inhibitor with >10-fold selectivity over mTORC2. It demonstrates superior mTORC1 inhibition and enhanced cytotoxicity in TSC2-null tumors compared to rapamycin, supporting its use in preclinical oncology research for mTOR pathway dysregulation.
Product Specifications
CAS Number
2382769-46-0
Field of Research
Signal Transduction
Smiles
[H][C@@]12CC[C@@H] (C) [C@@] (O) (O1) C (=O) C (=O) N1CCCC[C@@]1 ([H]) C (=O) O[C@@] ([H]) (C[C@@H] (O) [C@H] (C) \C=C (C) \[C@@H] (O) [C@@H] (OC) C (=O) [C@H] (C) C[C@H] (C) \C=C\C=C\C=C (C) \[C@H] (C2) OC) [C@H] (C) C[C@@H]1CC[C@@H] (OC (=O) NCCOCCOCCOCCOCCOCCOCCOCCOCCC (=O) NCCS (=O) (=O) c2ccc (C (=O) N3CCOc4ccc (cc4C3) -c3ccc (N) nc3) c (C) c2F) [C@@H] (C1) OC
Molecular Formula
C95H141FN6O27S
Molecular Weight
1850.25
Storage Conditions
-20°C
Notes
For research use only.
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