AP14145 hydrochloride
AP14145 hydrochloride is a potent and selective negative allosteric modulator of SK2 and SK3 channels (IC50 = 1.1 μM), with activity dependent on S508 and A533 residues. It demonstrates antiarrhythmic efficacy by prolonging the atrial effective refractory period in vivo, including in Vernakalant-resistant models of atrial fibrillation.
Product Specifications
CAS Number
2387505-59-9
Field of Research
Pharmacology & Drug Discovery
Smiles
Cl.C[C@@H] (Nc1nc2cccc (NC (C) =O) c2[nH]1) c1cccc (c1) C (F) (F) F
Molecular Formula
C18H18ClF3N4O
Molecular Weight
398.81
Storage Conditions
-20°C
Notes
For research use only.
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