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AP14145 hydrochloride

AP14145 hydrochloride is a potent and selective negative allosteric modulator of SK2 and SK3 channels (IC50 = 1.1 μM), with activity dependent on S508 and A533 residues. It demonstrates antiarrhythmic efficacy by prolonging the atrial effective refractory period in vivo, including in Vernakalant-resistant models of atrial fibrillation.

Product Specifications

CAS Number

2387505-59-9

Field of Research

Pharmacology & Drug Discovery

Smiles

Cl.C[C@@H] (Nc1nc2cccc (NC (C) =O) c2[nH]1) c1cccc (c1) C (F) (F) F

Molecular Formula

C18H18ClF3N4O

Molecular Weight

398.81

Storage Conditions

-20°C

Notes

For research use only.

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