MS33
MS33 is a potent, VHL-based PROTAC degrader of WDR5 with Kd values of 870 nM for VCB and 120 nM for WDR5. It induces proteasome-dependent degradation and is a valuable chemical probe for studying WDR5 biology in acute myeloid leukemia research, both in vitro and in vivo.
Product Specifications
CAS Number
2407449-11-8
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
CN1CCN (CC1) c1ccc (cc1NC (=O) c1c[nH]c (=O) cc1C (F) (F) F) -c1cccc (CN2CCN (CCNC (=O) CCCCCCCCCC (=O) N[C@H] (C (=O) N3C[C@H] (O) C[C@H]3C (=O) NCc3ccc (cc3) -c3scnc3C) C (C) (C) C) CC2) c1
Molecular Formula
C64H84F3N11O7S
Molecular Weight
1208.5
Storage Conditions
-20°C
Notes
For research use only.
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