MM-102 (TFA)
MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM with an estimated Ki 200 times more potent than the ARA peptide.
Product Specifications
CAS Number
1883545-52-5
Product Name Alternative
HMTase Inhibitor IX (TFA)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
WDR5
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MM-102-trifluoroacetate.html
Purity
99.68
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1(NC([C@@H](NC(C(NC(C(C)C)=O)(CC)CC)=O)CCCNC(N)=N)=O)CCCC1)NC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3.FC(F)(F)C(O)=O
Molecular Formula
C37H50F5N7O6
Molecular Weight
783.83
Precautions
H302, H315, H319, H335
References & Citations
[1]Karatas H, et al. High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J Am Chem Soc. 2013 Jan 16;135 (2) :669-682.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Cell Death Dis. 2022 Sep 6;13 (9) :770.|J Mol Endocrinol. 2021 Jan;66 (1) :45-57.|Proc Natl Acad Sci U S A. 2019 Feb 19;116 (8) :2961-2966. |Acta Pharmacol Sin. 2022 Feb;43 (2) :457-469.
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