MM-102 (TFA)

MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM with an estimated Ki 200 times more potent than the ARA peptide.

Product Specifications

CAS Number

[1883545-52-5]

Product Name Alternative

HMTase Inhibitor IX (TFA)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

WDR5

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MM-102-trifluoroacetate.html

Purity

99.68

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(C1(NC([C@@H](NC(C(NC(C(C)C)=O)(CC)CC)=O)CCCNC(N)=N)=O)CCCC1)NC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3.FC(F)(F)C(O)=O

Molecular Formula

C37H50F5N7O6

Molecular Weight

783.83

Precautions

H302, H315, H319, H335

References & Citations

[1]Karatas H, et al. High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J Am Chem Soc. 2013 Jan 16;135 (2) :669-682.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Cell Death Dis. 2022 Sep 6;13 (9) :770.|J Mol Endocrinol. 2021 Jan;66 (1) :45-57.|Proc Natl Acad Sci U S A. 2019 Feb 19;116 (8) :2961-2966. |Acta Pharmacol Sin. 2022 Feb;43 (2) :457-469.