BMS641
BMS641 (BMS-209641) is a selective RARβ agonist. BMS641 has a higher affinity for RARβ (Kd, 2.5 nM) that is 100 times higher than that for RARα (Kd, 225 nM) or RARγ (Kd, 223 nM) [1].
Product Specifications
CAS Number
[369364-50-1]
Product Name Alternative
BMS-209641
UNSPSC
12352005
Target
RAR/RXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bms641.html
Purity
98.12
Solubility
DMSO : 8.33 mg/mL (ultrasonic)
Smiles
CC1(C2=CC=C(/C=C/C3=C(C=C(C=C3)C(O)=O)Cl)C=C2C(C4=CC=CC=C4)=CC1)C
Molecular Formula
C27H23ClO2
Molecular Weight
414.92
References & Citations
[1]Germain P, et al. Rational design of RAR-selective ligands revealed by RARbeta crystal stucture. EMBO Rep. 2004;5 (9) :877-882.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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