NCB-0846
NCB-0846 is a potent, cell-permeable small molecule inhibitor targeting TNIK with an IC50 of 21 nM. It is utilized in biochemical and cellular research to investigate Wnt signaling pathways and has shown efficacy in reducing tumor growth in preclinical colorectal cancer models.
Product Specifications
CAS Number
1792999-26-8
Product Name Alternative
Betacatenin, beta-catenin, bcatenin, inhibit, Inhibitor, NCB 0846, NCB0846, NCB-0846, MAPK Kinase Kinase Kinase, MAP4K, TNIK, Wnt/b-catenin, Wnt, Wnt/betacatenin, Wnt/β-catenin, βcatenin
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Purity
97.04% (May vary between batches)
Solubility
DMSO:50 mg/mL (133.18 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.33 mM)
Smiles
O[C@H]1CC[C@H] (CC1) Oc1cccc2cnc (Nc3ccc4nc[nH]c4c3) nc12
Molecular Formula
C21H21N5O2
Molecular Weight
375.42
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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