PROTAC PD-1/PD-L1 degrader-1
PROTAC PD-1/PD-L1 degrader-1 is a heterobifunctional small molecule that induces lysosomal degradation of PD-L1 (IC50 = 39.2 nM), thereby blocking the PD-1/PD-L1 immunosuppressive axis. It restores T-cell function in co-culture models and is a valuable tool for investigating targeted protein degradation in cancer immunology research, both in vitro and in vivo.
Product Specifications
CAS Number
2447066-37-5
Product Name Alternative
PROTAC, PROTAC PD 1/PD L1 degrader 1, PROTAC PD1/PDL1 degrader1, PROTAC PD-1/PD-L-1 degrader-1, PROTAC PD-1/PD-L1 degrader-1, PDL1, PD-L1, PD1, PD-1/PD-L1, PD1/PDL1, PD-1
Field of Research
Cancer Biology; Immunology & Inflammation, Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery
Purity
99.07% (May vary between batches)
Smiles
N#CC1=CC=CC (=C1) COC2=CC (OCC3=CC=CC (C4=CC=C5OCCOC5=C4) =C3C) =C (Cl) C=C2CN6CCCCC6C (=O) N7CCN (C (=O) CCCC (=O) NC8=CC=CC=9C (=O) N (C (=O) C89) C%10C (=O) NC (=O) CC%10) CC7
Molecular Formula
C59H58ClN7O11
Molecular Weight
1076.59
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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