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PA-8

PA-8 is a selective, orally bioavailable small molecule antagonist of the PAC1 receptor. It potently inhibits PACAP-induced cAMP production and CREB phosphorylation in vitro (IC50 = 2 nM) and blocks PACAP-mediated aversive behavior and mechanical pain in vivo, making it a valuable tool for neuroscience and pain research.

Product Specifications

CAS Number

878437-15-1

Product Name Alternative

PA 8, PA8, PA-8, PACAP type I

Field of Research

Pharmacology & Drug Discovery

Purity

97.54% (May vary between batches)

Solubility

DMSO:22.5 mg/mL (65.72 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.84 mM)

Smiles

COc1cc (ccc1OCC=C) C1CC (=O) Nc2nc (N) [nH]c (=O) c12

Molecular Formula

C17H18N4O4

Molecular Weight

342.35

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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