PA-8
PA-8 is a selective, orally bioavailable small molecule antagonist of the PAC1 receptor. It potently inhibits PACAP-induced cAMP production and CREB phosphorylation in vitro (IC50 = 2 nM) and blocks PACAP-mediated aversive behavior and mechanical pain in vivo, making it a valuable tool for neuroscience and pain research.
Product Specifications
CAS Number
878437-15-1
Product Name Alternative
PA 8, PA8, PA-8, PACAP type I
Field of Research
Pharmacology & Drug Discovery
Purity
97.54% (May vary between batches)
Solubility
DMSO:22.5 mg/mL (65.72 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.84 mM)
Smiles
COc1cc (ccc1OCC=C) C1CC (=O) Nc2nc (N) [nH]c (=O) c12
Molecular Formula
C17H18N4O4
Molecular Weight
342.35
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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