Volasertib trihydrochloride
Volasertib trihydrochloride is a potent, orally active ATP-competitive inhibitor of PLK1, PLK2, and PLK3, inducing mitotic arrest and apoptosis. It demonstrates significant antitumor efficacy in both in vitro cellular assays and in vivo xenograft models across various cancer types, supporting its role in oncology research.
Product Specifications
CAS Number
946161-17-7
Field of Research
Cell Biology
Smiles
Cl.Cl.Cl.CC[C@H]1N (C (C) C) c2nc (Nc3ccc (cc3OC) C (=O) N[C@H]3CC[C@@H] (CC3) N3CCN (CC4CC4) CC3) ncc2N (C) C1=O |wU:28.29,5.1, wD:25.22, (16.69, , ; , -12.23, ;4.18, -12.23, ; -12.27,2.97, ; -10.94,3.74, ; -9.6,2.97, ; -8.27,3.74, ; -8.27,5.28, ; -9.6,6.05, ; -6.94,6.05, ; -6.94,2.97, ; -5.6,3.74, ; -4.27,2.97, ; -2.93,3.74, ; -1.6,2.97, ; -1.6,1.43, ; -.27, .66, ;1.07,1.43, ;1.07,2.97, ; -.27,3.74, ; -.27,5.28, ;1.07,6.05, ;2.4, .66, ;3.73,1.43, ;2.4, -.88, ;3.73, -1.65, ;3.73, -3.19, ;5.07, -3.96, ;6.4, -3.19, ;6.4, -1.65, ;5.07, -.88, ;7.74, -3.96, ;9.07, -3.19, ;10.4, -3.96, ;10.4, -5.5, ;11.74, -6.27, ;11.74, -7.81, ;12.51, -9.15, ;10.97, -9.15, ;9.07, -6.27, ;7.74, -5.5, ; -4.27,1.43, ; -5.6, .66, ; -6.94,1.43, ; -8.27, .66, ; -8.27, -.88, ; -9.6,1.43, ; -10.94, .66, ) |
Molecular Formula
C34H53Cl3N8O3
Molecular Weight
728.2
Storage Conditions
-20°C
Notes
For research use only.
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