HIV-1 inhibitor-45

HIV-1 inhibitor-45 is a potent HIV-1 RNase H inhibitor with an IC50 value of 0.067 μM. HIV-1 inhibitor-45 shows an antiviral activity. HIV-1 inhibitor-45 shows poor cell permeability (with an apparent permeability coefficient (Papp) lower than 0.48 x 10−6 cm/s) [1].

Product Specifications

CAS Number

[2677762-43-3]

UNSPSC

12352005

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hiv-1-inhibitor-45.html

Concentration

10mM

Purity

99.54

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1N(C(C2=CC(O)=C(O)C(O)=C2)=O)CCN(S(=O)(C3=CC=C(N)C=C3)=O)C1)NCC4=CC=CO4

Molecular Formula

C23H24N4O8S

Molecular Weight

516.52

References & Citations

[1]Zhang L, et, al. Design, synthesis, and biological evaluation of novel double-winged galloyl derivatives as HIV-1 RNase H inhibitors. Eur J Med Chem. 2022 Jun 26;240:114563.