ART812
ART812 is a potent, orally bioavailable small molecule inhibitor of DNA polymerase theta (Polθ), with an enzymatic IC50 of 7.6 nM and a cellular MMEJ inhibition IC50 of 240 nM. This inhibitor is a valuable research tool for studying DNA repair pathways, particularly in the context of cancer research, where Polθ is a promising therapeutic target.
Product Specifications
CAS Number
2607138-82-7
Product Name Alternative
DNASynthesis, DNA polymerase θ, DNA Synthesis, ART812, ART-812, ART 812, RNA Synthesis, RNASynthesis
Field of Research
Cell Biology, Molecular Biology
Purity
99.07% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.15 mM) ; DMSO:90 mg/mL (194.89 mM)
Smiles
CN (C (=O) [C@@H]1[C@H] (O) [C@H] (O) C (=O) N1c1cc (cc (C) n1) C (F) (F) F) c1ccc (F) c (Cl) c1
Molecular Formula
C19H16ClF4N3O4
Molecular Weight
461.79
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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