IRE1α kinase-IN-6
IRE1α kinase-IN-6 is a highly potent and selective inhibitor of the IRE1α kinase, demonstrating an IC50 of 4.4 nM. This compound is a valuable research tool for investigating the unfolded protein response (UPR) in cellular models and has been utilized in studies exploring endoplasmic reticulum stress in various disease contexts.
Product Specifications
CAS Number
2715123-88-7
Field of Research
Cell Biology, Signal Transduction
Smiles
N[C@H]1CC[C@@H] (CC1) Nc1ncnc2c (csc12) C (=O) Nc1c (Cl) ccc (NS (=O) (=O) c2ccccc2Cl) c1F |wU:4.7, wD:1.0, (-4, -5.39, ; -2.67, -4.62, ; -1.33, -5.39, ; , -4.62, ; , -3.08, ; -1.33, -2.31, ; -2.67, -3.08, ;1.33, -2.31, ;1.33, -.77, ;2.67, , ;2.67,1.54, ;1.33,2.31, ; ,1.54, ; -1.46,2.02, ; -2.37, .77, ; -1.46, -.48, ; ; -1.94,3.48, ; -.91,4.63, ; -3.45,3.8, ; -3.92,5.27, ; -2.89,6.41, ; -1.39,6.09, ; -3.37,7.87, ; -4.87,8.19, ; -5.91,7.05, ; -7.41,7.37, ; -7.89,8.83, ; -9.35,8.36, ; -6.42,9.31, ; -8.36,10.3, ; -7.33,11.44, ; -7.81,12.91, ; -9.31,13.23, ; -10.35,12.08, ; -9.87,10.62, ; -10.9,9.48, ; -5.43,5.59, ; -6.46,4.44, ) |
Molecular Formula
C25H23Cl2FN6O3S2
Molecular Weight
609.52
Storage Conditions
-20°C
Notes
For research use only.
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