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HPK1-IN-4

HPK1-IN-4 is a potent and selective preclinical inhibitor of hematopoietic progenitor kinase 1 (HPK1/MAP4K1) with an IC50 of 0.061 nM. This tool compound is utilized in immunological research to investigate HPK1's role in T-cell signaling and function, supporting both in vitro cellular assays and in vivo efficacy studies in preclinical cancer immunotherapy models.

Product Specifications

CAS Number

2739844-28-9

Product Name Alternative

MAP4K, HPK1IN4, HPK-1-IN-4, HPK1-IN-4, HPK1, HPK1 IN 4

Field of Research

Signal Transduction

Purity

97.06% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.3 mM) ; DMSO:90 mg/mL (207.14 mM)

Smiles

COc1cc2CCN (C) Cc2cc1Nc1ncc (C (N) =O) c (Nc2ccccc2CO) n1

Molecular Formula

C23H26N6O3

Molecular Weight

434.49

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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