EM 163
EM 163 is a MyD88 TIR domain mimetic that inhibits TIR-TIR interactions, specifically blocking IL-1 receptor signaling. It reduces inflammatory cytokine production in vivo, protecting mice from SEB-induced shock, and in vitro, it blocks IL-1β-mediated p38 activation and impairment of protein synthesis in neuronal LTP models.
Product Specifications
CAS Number
1206480-93-4
Product Name Alternative
ILReceptor, IL-1β, IL Receptor, MyD88, EM163, EM-163, EM 163, TIR1/AFB receptor, p38MAPK, p38, p38 MAPK
Field of Research
Cell Biology, Immunology & Inflammation, Signal Transduction
Purity
97.97% (May vary between batches)
Solubility
DMSO:40 mg/mL (47.07 mM)
Smiles
N ([C@H] (C (=O) N1CCCC1) C (C) C) (C (=O) C2=C[N+] (C) =C (C (N ([C@H] (C (=O) N3CCCC3) C (C) C) CCCC4=CC=CC=C4) =O) C=C2) CCCC5=CC=CC=C5.[I-]
Molecular Formula
C44H60IN5O4
Molecular Weight
849.88
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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