Phototrexate
Phototrexate is a photoswitchable methotrexate analog that acts as a potent inhibitor of human DHFR. Its antifolate activity is activated to a cis-form (IC50 = 6 nM) by 375 nm UVA light and deactivated to a trans-form by blue light or thermally. This enables precise, light-controlled modulation of cell proliferation in cancer research models like HeLa cells.
Product Specifications
CAS Number
2268033-83-4
Field of Research
Cell Biology, Metabolism Research, Molecular Biology
Smiles
NC=1C2=C (C=CC (/N=N/C3=CC=C (C (N[C@@H] (CCC (O) =O) C (O) =O) =O) C=C3) =C2) N=C (N) N1
Molecular Formula
C20H19N7O5
Molecular Weight
437.41
Storage Conditions
-20°C
Notes
For research use only.
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