Verrucarin A
Verrucarin A is a macrocyclic mycotoxin and protein synthesis inhibitor derived from Myrothecium verrucaria. It exhibits potent anti-leukemic activity in vitro by inducing apoptosis, modulating p38/ERK/Akt signaling, and deregulating the cell cycle via p53/p21. Its effects on inflammatory pathways in macrophages make it a compound of interest for oncology and immunology research.
Product Specifications
CAS Number
3148-09-2
Product Name Alternative
Muconomycin-A; 379-Y; Glutinosin-I; Myrothecin-I; NSC-126728
Field of Research
Cell Biology
Purity
>98%
Bioactivity
Steroid receptor coactivator-3 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml)
Smiles
CC12[C@@]3 ([C@@]4 (O[C@]5 ([C@]1 (COC (=O) [C@@H] (O) [C@H] (C) CCOC (=O) \C=C\C=C\C (=O) O[C@@]2 (C4) [H]) CCC (C) =C5) [H]) [H]) CO3
Molecular Formula
C27H34O9
Molecular Weight
502.6
References & Citations
Storage Conditions
-20°C
Notes
For research use only.
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