GCN2iB (acetate)
GCN2iB acetate is a GCN2 inhibitor that enhances Gcn2 activity and Atf4 expression. GCN2iB can activate Gcn2 mutants lacking functional regulatory regions or certain kinase domain substitution mutants. GCN2iB increases eIF2 phosphorylation by Gcn2 at low concentrations, thereby enhancing the cellular response to nutritional stress. GCN2iB may have potential benefits for the inhibition of cancer cells expressing low basal levels of aspartate synthetase, enhancing their sensitivity to the anti-leukemic compound L-aspartase[1].
Product Specifications
CAS Number
[2183470-13-3]
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gcn2ib-acetate.html
Smiles
O=S(C1=CC(Cl)=CN=C1OC)(NC2=CC=C(C(C#CC3=CN=C(N=C3)N)=C2F)F)=O.CC(O)=O
Molecular Formula
C20H16ClF2N5O5S
Molecular Weight
511.89
References & Citations
[1]Activation of Gcn2 by small molecules designed to be inhibitors
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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