Lazertinib
Lazertinib (GNS-1480) is a potent, irreversible, and mutant-selective EGFR tyrosine kinase inhibitor. It demonstrates high potency against oncogenic EGFR mutants, particularly Del19/T790M and L858R/T790M, with significantly lower activity against wild-type EGFR. This profile supports its research use in vitro and in vivo for studying resistance mechanisms and targeted therapies in non-small cell lung cancer.
Product Specifications
CAS Number
1903008-80-9
Product Name Alternative
YH 25448, YH25448, YH-25448, inhibit, HER1, Inhibitor, Lazertinib, Lazertinib (YH25448), GNS 1480, GNS1480, GNS-1480, Epidermal growth factor receptor, EGFR, EGFR (del19), EGFR (T790M), EGFR (T790M/L858R), EGFR (wildtype), ErbB-1
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.70% (May vary between batches)
Solubility
H2O:Insoluble; DMSO:6 mg/mL (10.82 mM) ; Ethanol:Insoluble
Smiles
COc1cc (N2CCOCC2) c (NC (=O) C=C) cc1Nc1nccc (n1) -n1cc (CN (C) C) c (n1) -c1ccccc1
Molecular Formula
C30H34N8O3
Molecular Weight
554.64
Storage Conditions
-20°C
Notes
For research use only.
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